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KMID : 0380020080230050449
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Korean Journal of Biotechnology and Bioengineering
2008 Volume.23 No. 5 p.449 ~ p.451
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The ceramide contents of Saccharomyces cerevisiae in batch culture
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Abstract
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Ceramide has become a widely used ingredient in cosmetic and pharmaceutical industries, however, only a few yeast strains were investigated for the synthesis of ceramide and the concentration was very low. Ceramide is not only a core intermediate of sphingolipids but also an important modulator of many cellular events including apoptosis, cell cycle arrest, senescence, differentiation, and stress responses. In this study S.cerevisiae was grown in a batch culture and the cellular content of ceramide was measured at different growth phases. The ceramide content was highest at stationary phase and 2.01 mg ceramide/g cell was obtained.
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KEYWORD
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Saccharomyces cerevisiae, ceramide, growth phases
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